Tiny chips hitch a ride on immune cells to sites of inflammation

Researchers at MIT have unveiled a groundbreaking advancement in brain implant technology, developing tiny electronic devices that can hitch a ride on immune cells. Unlike standard brain implants that require surgical procedures and penetrate brain matter, these innovative devices can be injected into the bloodstream using a simple syringe. Led by Deblina Sarkar, an electrical engineer and assistant professor at MIT, the team faced significant challenges in the early stages of their research. Sarkar revealed that they submitted 35 grant proposals that were all rejected, with reviewers commenting on the high impact of their concept but deeming it impossible. The idea, which initially resembled something out of a science fiction novel, has now become a reality after more than six years of persistent research. In 2022, following promising initial results with their hybrid cell-electronics technology, the team submitted their project for the National Institutes of Health Director’s New Innovator Award. This time, it successfully passed peer review, achieving the highest impact score ever recorded for such a proposal. Sarkar noted that the technology addresses three major challenges in the field. The first challenge was creating functional electronic devices smaller than blood cells that could navigate the circulatory system. Previous attempts focused on using magnetic particles guided by magnetic fields, but Sarkar pointed out the distinction between electronics and simple particles. Using CMOS technology, which is also employed in computer processors, these devices can generate electrical power from incoming light, akin to photovoltaics, and perform complex computations for advanced applications, such as sensing. In contrast, traditional particles have limited capabilities when it comes to stimulating cells. This innovative approach not only opens new avenues for brain research but also paves the way for less invasive treatment options, potentially transforming how neurological conditions are addressed in the future.